CONTENTS

Polysaccharide of Salmonella typhi.

PRESENTATION

Prefilled syringe 25 mcg/0.5 mL x 1's.

DESCRIPTION

Each 0.5-mL dose contains polysaccharide of Salmonella typhi Ty2 strain 25 mcg.

It also contains the following ingredients: Phenol and a buffer solution containing sodium chloride, disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate and water for injection.

INDICATIONS

Prevention of typhoid fever in adults and children >2 years.

Typhim Vi is especially indicated for travellers to endemic areas, migrants, healthcare professionals and military personnel.

DOSAGE & ADMINISTRATION

A single injection ensures protection. Revaccination should be performed every 3 years if the risk of exposure continues.

The vaccination schedule is the same for children and adults.

Typhim Vi should be administered by IM or SC routes.

CONTRAINDICATIONS

Hypersensitivity to any of the components of Typhim Vi.

Do not inject by IM route to patients with bleeding disorders eg, hemophilia or thrombocytopenia.

Use in children: Typhim Vi is not indicated in children <2 years because efficacy is not adequate in this age group.

PRECAUTIONS

Fever, acute disease, progressive chronic disease (vaccination should be postponed).

Typhim Vi must not be injected by the intravascular route, make sure the needle does not penetrate a blood vessel.

Typhim Vi protects against typhoid fever bacterium (Salmonella typhi), but not against related bacteria (Salmonella paratyphi A or B).

For any vaccine, adverse events following immunization should be monitored. Although anaphylactic reaction is rare, medications for anaphylaxis treatment should always be available at the time of vaccination.

Use in pregnancy & lactation: Because of the seriousness of the disease and in case of high risk of exposure to typhoid fever, pregnancy is not a reason not to administer the vaccine.

Typhim Vi should be used during pregnancy only when advised by the physician.

Typhim Vi may be used during lactation.

SIDE EFFECTS

The effects reported after vaccination are usually moderate and of short duration.

Local Injection Site Reactions: Pain, swelling, redness.

Rare General Reactions: Fever, tiredness, headache, malaise, joint and muscle pain, nausea, abdominal pain.

Very Rare Allergic Reactions: Itching, skin rash, urticaria.

Isolated cases of serum sickness and serious allergic reactions (anaphylactic reactions) have been reported.

INTERACTIONS

Typhim Vi may be given together with other vaccines (hepatitis A, yellow fever, diphtheria, tetanus, poliomyelitis, rabies, meningitis A + C and hepatitis B) during the same vaccination session.

STORAGE

Store in a refrigerator (2-8°C). Do not freeze.

Shelf-Life: 36 months.